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The aim of this study was to validate registration of pharmacological treatment in the Danish Hip Arthroplasty Register (DHR) and Danish Knee Arthroplasty Register (DKR). We conducted a population-based study in the Capital Region of Denmark, January 2012 to April 2016. Positive predictive value (PPV) and sensitivity were calculated with 95% confidence intervals (CI) for antithrombotic, antihemorr

https://www.lupop.lu.se/article/validation-registration-pharmacological-treatment-danish-hip-and-knee-arthroplasty-registers - 2025-11-09

Chronic urticaria (CU) is a common disease, characterized by the recurrent appearance of wheals, angioedema or both for more than 6 weeks. Its underlying biology is not well understood, and many patients do not obtain sufficient relief from recommended treatments. Patient registries are rapidly growing as a form of research, because they can provide powerful, data‐driven insights about the epidemi

https://www.lupop.lu.se/article/chronic-urticaria-registry-rationale-methods-and-initial-implementation - 2025-11-09

Variation in the incidence, survival rate and factors associated with survival after cardiac arrest in Europe is reported. Some studies have tried to fill the knowledge gap regarding the epidemiology of out-of-hospital cardiac arrest in Europe but were unable to identify reasons for the reported differences. Therefore, the purpose of this study was to describe European Emergency Medical Systems, p

https://www.lupop.lu.se/article/description-emergency-medical-services-treatment-cardiac-arrest-patients-and-cardiac-arrest - 2025-11-09

Between 2012 and 2016, 30,607 presentations in MM were recorded corresponding to 17,748 individual patients (mean age 62.1 years (SD 18.4); 10,961 (61.8%) males). BJI was considered as complex for 63% of cases (n = 19,355), and 13,376 (44%) had prosthetic joint infections (PJIs). The controlled dataset, available for 19 centres, included 283 patients. Global consistency and completeness were estim

https://www.lupop.lu.se/article/computerized-registry-potential-tool-surveillance-and-management-complex-bone-and-joint-infections - 2025-11-09

Diagnostic delay (DD) is especially relevant in children with inflammatory bowel disease, leading to potential complications. We examined the intervals and factors for DD in the pediatric population of Spain. Read more at Frontiers | Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica |

https://www.lupop.lu.se/article/spanish-pediatric-inflammatory-bowel-disease-diagnostic-delay-registry-spider-study-sociedad - 2025-11-09

SNAR includes data from patients with asthma (both children and adults) and COPD from primary, secondary and tertiary care, and also, for COPD inpatient care. Data on diagnostic investigations (e.g. spirometry, blood sample, skin prick test), symptom-scores, comorbidities and prescribed treatments are registered. The registrations are entered manually by healthcare professionals, or directly trans

https://www.lupop.lu.se/article/swedish-national-airway-register-snar-development-design-and-utility-date - 2025-11-09

Sexual and Reproductive Health and Rights (SRHR) is a concept of human rights applied to sexuality and reproduction. Suboptimal access to SRHR services in many low-income countries results in poor health outcomes. Sustainable development goals (3.7 and 5.6) give a new impetus to the aspiration of universal access to high-quality SRHR services. Indispensable stakeholders in this process are healthc

https://www.lupop.lu.se/article/predictors-health-care-practitioners-normative-attitudes-and-practices-towards-sexual-and - 2025-11-09

A prospective observational study in eight different PHC centres in Sweden including 192 women with symptoms of uncomplicated UTI. Questionnaires and symptom diaries were used to retrieve patient data. All urine samples were analysed with urine culture and susceptibility testing. The aim was to describe the clinical presentation of symptoms in uncomplicated UTI in relation to bacterial findings in

https://www.lupop.lu.se/article/uncomplicated-urinary-tract-infection-primary-health-care-presentation-and-clinical-outcome - 2025-11-09

All patients with schizophrenia who experienced AMI during 2000-2018 were identified (n=1008) from the nationwide Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry and compared with AMI patients without schizophrenia (n=2 85 325). Kaplan-Meier survival curves and multivariable Cox regression models were

https://www.lupop.lu.se/article/higher-risk-major-adverse-cardiac-events-after-acute-myocardial-infarction-patients-schizophrenia - 2025-11-09

Self-exclusion from gambling is a common method for prevention and harm reduction in hazardous gambling. However, few national self-exclusion programs, involving a large number of gambling operators and activities in a country, have been assessed scientifically. This study aimed to examine characteristics of individuals who chose to enroll in a recently introduced (January, 2019) national self-exc

https://www.lupop.lu.se/article/who-chooses-enroll-new-national-gambling-self-exclusion-system-general-population-survey-sweden - 2025-11-09

Lung cancer is the worldwide leading cause of death from cancer. Epigenetic modifications such as methylation and changes in chromatin accessibility are major gene regulatory mechanisms involved in tumorigenesis and cellular lineage commitment. We aimed to characterize these processes in the context of neuroendocrine (NE) lung cancer. Illumina 450K DNA methylation data were collected for 1407 lung

https://www.lupop.lu.se/article/methylation-patterns-and-chromatin-accessibility-neuroendocrine-lung-cancer - 2025-11-09

Although the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid (Aβ) pathway, the high prevalence of apolipoprotein E ε4 (APOE ε4) in Alzheimer disease and the ease of identifying ε4 carriers make the APOE genotype and its corresponding protein (apoE) an appealing therapeutic target to slow Aβ accumulation. Read more at Association Between Apolipopr

https://www.lupop.lu.se/article/association-between-apolipoprotein-e-e2-vs-e4-age-and-b-amyloid-adults-without-cognitive-impairment - 2025-11-09

Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors. Read more at

https://www.lupop.lu.se/article/psychiatric-disorders-offspring-childhood-or-adolescent-central-nervous-system-tumor-survivors - 2025-11-09

With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants. Read more at Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age: an

https://www.lupop.lu.se/article/prelabour-caesarean-section-and-neurodevelopmental-outcome-4-and-12-months-age-observational-study - 2025-11-09

Middle Eastern immigrants to Europe represent a high risk population for type 2 diabetes. We compared prevalence of novel subgroups and assessed risk of diabetic macro‐ and microvascular complications between diabetes patients of Middle Eastern and European origin. Read more at Adult‐onset diabetes in Middle Eastern immigrants to Sweden: Novel subgroups and diabetic complications—The All New Diabe

https://www.lupop.lu.se/article/adult-onset-diabetes-middle-eastern-immigrants-sweden-novel-subgroups-and-diabetic-complications-all - 2025-11-09

The epidemiological association between diabetes and cardiovascular disease is well established, but the pathophysiological link is complex and multifactorial. We investigated seven proteins, previously linked to incident diabetes mellitus, and their association with cardiovascular disease and mortality. Read more at Proteomic exploration of common pathophysiological pathways in diabetes and cardi

https://www.lupop.lu.se/article/proteomic-exploration-common-pathophysiological-pathways-diabetes-and-cardiovascular-disease - 2025-11-09

Circulating cell‐free nuclear DNA (nDNA) has been implicated in individual cancer types with a diagnostic value; however, the role of cell‐free mitochondrial DNA (mtDNA) in cancers is controversial. We aimed to investigate and compare the diagnostic potential of both nDNA and mtDNA for multiple cancers and to investigate their ability to distinguish multiple cancers from healthy controls and from

https://www.lupop.lu.se/article/diagnostic-potential-circulating-cell-free-nuclear-and-mitochondrial-dna-several-cancer-types-and - 2025-11-09

It has been suggested that a high intake of sugar or sweeteners may result in an unfavorable microbiota composition; however, evidence is lacking. Hence, in this exploratory epidemiological study, we aim to examine if intake of added sugar, sugar-sweetened beverages (SSBs) or artificially sweetened beverages (ASBs) associate with the gut microbiota composition. Read more at Gut microbiota composit

https://www.lupop.lu.se/article/gut-microbiota-composition-relation-intake-added-sugar-sugar-sweetened-beverages-and-artificially - 2025-11-09

Breast cancer is one of the most common cancer forms in women and it is often detected by screening. However, women with drug use disorders (DUD) are less likely to be reached by screening programs. In this study, we aimed to investigate breast cancer incidence, mortality and stage at time of diagnosis among women with DUD compared to the general female population in Sweden. Read more at Drug use

https://www.lupop.lu.se/article/drug-use-disorder-and-risk-incident-and-fatal-breast-cancer-nationwide-epidemiological-study - 2025-11-09

A lipidomic approach was utilized to analyze plasma from 67 healthy adolescent subjects (10–15 years of age) with or without islet autoantibodies but all with increased genetic risk for T1D. The study subjects were enrolled at birth in the Diabetes Prediction in Skåne (DiPiS) study and after 10–15 years of follow-up we performed the present cross-sectional analysis. HLA-DRB345, -DRB1, -DQA1, -DQB1

https://www.lupop.lu.se/article/characterization-plasma-lipidomics-adolescent-subjects-increased-risk-type-1-diabetes-dipis-cohort - 2025-11-09